A mitochondria-targeting tetrapeptide, also known as elamipretide, studied clinically for mitochondrial diseases and other conditions involving mitochondrial dysfunction.
Mechanism under study
SS-31 concentrates in the inner mitochondrial membrane and binds the phospholipid cardiolipin. This is proposed to stabilize cristae structure, support efficient electron transport, and reduce reactive-oxygen-species production.
Research-reported dosing
Investigational (as elamipretide). Clinical trials in mitochondrial disease and related conditions used roughly 40 mg/day subcutaneously. Not approved.
Based on a standard 10 mg vial: with 2 mL bacteriostatic water = 5,000 mcg/mL (5 mg/mL); 1 unit ≈ 50 mcg.
Open this mix in the calculator →Source research-grade SS-31 ↗Dosing figures describe how this compound appears in the research literature and research-community references. They are not a recommendation for human use.
SS-31 FAQ
What is SS-31?
A mitochondria-targeting tetrapeptide, also known as elamipretide, studied clinically for mitochondrial diseases and other conditions involving mitochondrial dysfunction.
What is the half-life of SS-31?
Reported short in circulation (on the order of a few hours) after subcutaneous dosing in clinical studies.
What is the research-reported dosing for SS-31?
Investigational (as elamipretide). Clinical trials in mitochondrial disease and related conditions used roughly 40 mg/day subcutaneously. Not approved.
How is SS-31 reconstituted?
Based on a standard 10 mg vial: with 2 mL bacteriostatic water = 5,000 mcg/mL (5 mg/mL); 1 unit ≈ 50 mcg.
Is SS-31 FDA-approved?
No — SS-31 is investigational and not FDA-approved. It is sold for laboratory research use only.
References
Guides featuring SS-31
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