Peptide guides, written to inform.
Long-form, evidence-based deep dives — mechanisms, what the research does and doesn't support, dosing references, comparisons, and safety. No marketing copy.
Semaglutide vs. Tirzepatide vs. Retatrutide: Choosing an Incretin
Semaglutide, tirzepatide, and retatrutide represent single-, dual-, and triple-receptor incretin agonism, a progression that trial data link to greater reported weight loss but that also carries very different approval and safety realities.
- The three map onto escalating receptor coverage: semaglutide (GLP-1 only), tirzepatide (GIP plus GLP-1), and retatrutide (GIP plus GLP-1 plus glucagon).
- Trial-reported average weight loss broadly increases across that progression, but retatrutide's highest figures come from a phase 2 study and remain investigational.
Start here
The fundamentals every researcher should read first.
How to Reconstitute Peptides & How Much Bacteriostatic Water to Use
How to reconstitute peptides step by step: how much bacteriostatic water to use, the concentration math, mixing technique, reading insulin-syringe units, and storage. Research use.
Peptide Safety: Side Effects, Sterility, and Research Risks
An educational overview of how research peptides are discussed in terms of safety: common categories of reported effects, sterility and injection-site practices, why sourcing and certificates of analysis matter, and the research-use-only frame.
GLP-1 & Metabolic
02GLP-1 & MetabolicGLP-1 Receptor Agonists: Semaglutide, Tirzepatide, and Retatrutide Explained
An educational overview of the GLP-1 receptor agonist class — how incretin biology works and how semaglutide, tirzepatide, and retatrutide compare on receptor targets, approval status, trial-reported weight loss, titration, and safety.
Read guide →GLP-1 & MetabolicGLP-1 Side Effects and Why Titration Matters
Why GLP-1 receptor agonists cause the GI effects they do, how slow dose titration reduces them, the less-common concerns raised in clinical trials, and the difference between approved prescription products and research-grade material.
Read guide →Healing & Recovery
03Healing & RecoveryBPC-157: What the Research Actually Shows
A research-focused overview of BPC-157, the synthetic pentadecapeptide studied in preclinical models for angiogenesis and tissue repair — its origin, proposed mechanisms, evidence by tissue, limitations, reconstitution, and regulatory status.
Read guide →Healing & RecoveryTB-500 and Thymosin Beta-4: A Research Overview
A research overview of TB-500 and its parent molecule thymosin beta-4: actin regulation and cell migration, angiogenesis and inflammation modulation, preclinical evidence by tissue, reconstitution, dosing conventions, and anti-doping status.
Read guide →Healing & RecoveryBPC-157 & TB-500: The Recovery Stack
Why researchers pair BPC-157 with TB-500, the complementary mechanisms behind the so-called Wolverine stack, research-reported amounts and cycling, how a blend is reconstituted, and the safety and regulatory realities.
Read guide →Growth Hormone
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Growth HormoneCJC-1295 & Ipamorelin: The GH Secretagogue Stack
Why CJC-1295 and ipamorelin are studied together: complementary growth-hormone-secretagogue mechanisms, DAC versus no-DAC, timing rationale in research, and safety context.
Read guide →Growth HormoneGrowth Hormone Peptides Explained: GHRH vs GHRP vs MK-677
A clear breakdown of the three ways research compounds nudge growth-hormone output: GHRH analogs like sermorelin and tesamorelin, ghrelin-receptor GHRPs like ipamorelin, and the oral non-peptide MK-677 — plus how they synergize and where they stand legally.
Read guide →Longevity
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Sexual Health
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Cosmetic & Skin
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Cosmetic & SkinGHK-Cu: The Copper Peptide, From Skin Science to Research Use
A research-focused deep dive into GHK-Cu, the naturally occurring copper-binding tripeptide studied for skin, collagen, gene expression, and tissue remodeling — covering discovery, mechanism, evidence by route, reconstitution math, and safety framing.
Read guide →Cosmetic & SkinMelanotan I vs Melanotan II: Tanning Peptides in Research
How the melanocortin pathway drives tanning, the difference between MC1R-selective afamelanotide (Melanotan I, approved as Scenesse) and the broader-acting Melanotan II, the arousal effect that led to PT-141, and the documented safety and regulatory picture.
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