SS-31 Dosage Chart & Schedule
A mitochondria-targeting tetrapeptide, also known as elamipretide, studied clinically for mitochondrial diseases and other conditions involving mitochondrial dysfunction.
SS-31 (elamipretide) is a mitochondria-targeting tetrapeptide studied in mitochondrial disease and related conditions. Clinical trials used roughly 40 mg per day subcutaneously; it is investigational and not approved.
Figures describe how SS-31 is reported in the research literature and research-community references — not a recommendation for human use. For laboratory research only.
Dosage protocols
Commonly referenced research tiers. Start conservative; every compound and study context differs.
- Frequency
- Once daily
- Weekly total
- ~280 mg/week
- Cycle
- Weeks to months in trials
Investigational as elamipretide; a single well-characterized clinical dose, so no titration ladder is shown.
Investigational (elamipretide)
- Studied in mitochondrial disease and other conditions involving mitochondrial dysfunction.
- Not approved; the 40 mg/day figure is from clinical trials.
Mitochondria-targeting
- Concentrates in the inner mitochondrial membrane and binds cardiolipin, proposed to stabilize cristae and support electron transport.
Ready to run this protocol?
Dosing is only as good as the vial. SS-31 is third-party tested with published COAs from our top-rated source — reconstitute with confidence and skip the guesswork on identity and purity.
Weekly schedule
A typical week on the trial reference dose protocol (Once daily).
Dosing day Off
From vial to injection in 6 steps
Wipe both vial tops
Swab the peptide vial and the bacteriostatic-water vial with fresh alcohol and let them dry.
Draw the water
Pull the planned amount of bacteriostatic water (2 mL) into the syringe.
Add it slowly
Run the water down the inside wall of the vial — don't blast the powder. Swirl gently; never shake.
Let it dissolve
Wait until the solution is fully clear, then refrigerate the vial.
Draw your dose
Pull the calculated units on a U-100 insulin syringe.
Store between uses
Keep the reconstituted vial refrigerated and use within its stable window.
Handling & storage
- Clinical elamipretide used a concentrated 40 mg/mL solution; a typical 10 mg research vial in 2 mL (5 mg/mL) cannot hold a full 40 mg dose, so research handling and doses differ from the trial regimen.
- In trials it was given once daily by subcutaneous injection.
- Refrigerate the reconstituted solution and protect it from light.
SS-31 dosing FAQ
What dose was used in trials?
Clinical studies in mitochondrial disease and related conditions used roughly 40 mg per day subcutaneously.
How often is SS-31 dosed?
Trials used once-daily subcutaneous administration; its circulating half-life is reported as a few hours.
Is SS-31 approved?
No. As elamipretide it remains investigational, so the 40 mg/day figure is a trial reference rather than a recommendation.
Why is only one dose shown?
The literature centers on a single well-characterized daily trial dose, so a starter-to-maintenance ladder would not reflect the evidence.
Sources
Categories: Longevity & Cellular · Status: Investigational. This page is educational and for laboratory research use only; it is not medical advice.