Glutathione (GSH) is an endogenous tripeptide of glutamate, cysteine, and glycine that serves as a master intracellular antioxidant and cofactor for detoxification enzymes. It is researched and used across several routes - IV, subcutaneous, nebulized, and oral/liposomal - for oxidative-stress, hepatic, and dermatologic contexts. Oral bioavailability of standard forms is poor.
Mechanism under study
The reactive thiol on its cysteine residue neutralizes reactive oxygen species and serves as substrate for glutathione peroxidases and S-transferases, supporting redox balance, xenobiotic detoxification, and regeneration of other antioxidants such as vitamins C and E.
Research-reported dosing
Highly route-dependent: IV research/clinical use cites roughly 600-2,400 mg per session; nebulized and subcutaneous protocols use smaller amounts; liposomal oral products aim to offset poor gut absorption. Not FDA-approved as a therapeutic drug (available in compounded injectable and dietary-supplement forms); protocols vary widely.
Based on a standard 1500 mg vial: with 5 mL bacteriostatic water = 300,000 mcg/mL (300 mg/mL); 1 unit ≈ 3 mg.
Open this mix in the calculator →Source research-grade Glutathione ↗Dosing figures describe how this compound appears in the research literature and research-community references. They are not a recommendation for human use.
Glutathione FAQ
What is Glutathione?
Glutathione (GSH) is an endogenous tripeptide of glutamate, cysteine, and glycine that serves as a master intracellular antioxidant and cofactor for detoxification enzymes. It is researched and used across several routes - IV, subcutaneous, nebulized, and oral/liposomal - for oxidative-stress, hepatic, and dermatologic contexts. Oral bioavailability of standard forms is poor.
What is the half-life of Glutathione?
Short in plasma - on the order of minutes for IV glutathione - reflecting rapid turnover and enzymatic recycling.
What is the research-reported dosing for Glutathione?
Highly route-dependent: IV research/clinical use cites roughly 600-2,400 mg per session; nebulized and subcutaneous protocols use smaller amounts; liposomal oral products aim to offset poor gut absorption. Not FDA-approved as a therapeutic drug (available in compounded injectable and dietary-supplement forms); protocols vary widely.
How is Glutathione reconstituted?
Based on a standard 1500 mg vial: with 5 mL bacteriostatic water = 300,000 mcg/mL (300 mg/mL); 1 unit ≈ 3 mg.
Is Glutathione FDA-approved?
Glutathione has an approved status in at least one context — see the overview above for the specific brand, region, and indication. Research-grade material sold separately is for laboratory use only.
References
Related peptides
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Epithalon
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