Glutathione Dosage Chart & Schedule
Glutathione (GSH) is an endogenous tripeptide of glutamate, cysteine, and glycine that serves as a master intracellular antioxidant and cofactor for detoxification enzymes. It is researched and used across several routes - IV, subcutaneous, nebulized, and oral/liposomal - for oxidative-stress, hepatic, and dermatologic contexts. Oral bioavailability of standard forms is poor.
Glutathione dosing is highly route-dependent. IV research and clinical use cites roughly 600-2,400 mg per session (diluted into saline), while intramuscular, subcutaneous, and nebulized protocols use smaller amounts. It is not FDA-approved as a therapeutic drug.
Figures describe how Glutathione is reported in the research literature and research-community references — not a recommendation for human use. For laboratory research only.
Dosage protocols
Commonly referenced research tiers. Start conservative; every compound and study context differs.
- Frequency
- 1-3x per week
- Weekly total
- ~600-1,800 mg/week
- Cycle
- Varies
Smaller per-dose amounts used outside an IV setting.
- Frequency
- 1-2x per week
- Weekly total
- ~600-2,400 mg/week
- Cycle
- Varies
The most commonly cited IV research/clinical range.
- Frequency
- 1-2x per week
- Weekly total
- Varies
- Cycle
- Varies
Upper end of reported IV session amounts.
Route decides the dose
- The reactive thiol on the cysteine residue neutralizes reactive oxygen species and feeds detoxification enzymes, so glutathione is studied across oxidative-stress and hepatic contexts.
- Standard oral forms have poor bioavailability, which is why injectable, IV, nebulized, and liposomal routes are used; IV levels far exceed injectable-peptide norms.
Ready to run this protocol?
Dosing is only as good as the vial. Glutathione is third-party tested with published COAs from our top-rated source — reconstitute with confidence and skip the guesswork on identity and purity.
Weekly schedule
A typical week on the iv session (standard) protocol (1-2x per week).
Dosing day Off
From vial to injection in 6 steps
Wipe both vial tops
Swab the peptide vial and the bacteriostatic-water vial with fresh alcohol and let them dry.
Draw the water
Pull the planned amount of bacteriostatic water (5 mL) into the syringe.
Add it slowly
Run the water down the inside wall of the vial — don't blast the powder. Swirl gently; never shake.
Let it dissolve
Wait until the solution is fully clear, then refrigerate the vial.
Draw your dose
Pull the calculated units on a U-100 insulin syringe.
Store between uses
Keep the reconstituted vial refrigerated and use within its stable window.
Handling & storage
- Glutathione oxidizes readily and is light-sensitive; keep it refrigerated, protect from light, and use soon after reconstituting.
- The 1,500 mg vial is large; with 5 mL of bacteriostatic water that is 300 mg/mL.
- Larger IV doses are further diluted into saline rather than given as a small U-100 unit volume.
- Not FDA-approved as a therapeutic drug; available in compounded injectable and dietary-supplement forms, and protocols vary widely.
Glutathione dosing FAQ
How much glutathione per dose?
It depends on route. IV sessions commonly cite roughly 600-2,400 mg, while intramuscular, subcutaneous, and nebulized protocols use smaller amounts.
Is glutathione injected as U-100 syringe units?
Small IM/subQ amounts can be, but larger IV doses are diluted into saline and given as a slow push or drip, not measured in insulin-syringe units.
How is the 1,500 mg vial reconstituted?
Reconstituting the 1,500 mg vial with 5 mL of bacteriostatic water gives 300 mg/mL. For IV use, the drawn dose is then further diluted into saline.
Why not just take glutathione orally?
Standard oral glutathione has poor absorption, which is why research uses IV, IM, subcutaneous, nebulized, or liposomal-oral routes; the injectable routes bypass the gut.
Is glutathione an approved drug?
No. It is not FDA-approved as a therapeutic; it exists in compounded injectable and dietary-supplement forms, and dosing protocols vary widely.
Sources
Categories: Longevity & Cellular · Status: Approved (see notes). This page is educational and for laboratory research use only; it is not medical advice.