SNAP-8 (Acetyl Octapeptide-3) is a topical cosmetic peptide marketed as a neuromodulating anti-wrinkle ingredient. It is an eight-amino-acid fragment modeled on the N-terminus of SNAP-25 and is used in leave-on skincare rather than by injection. Evidence is largely manufacturer- and cosmetic-study based.
Mechanism under study
Proposed to compete with SNAP-25 in the SNARE complex that mediates neurotransmitter-vesicle docking, theoretically reducing the intensity of muscle contraction and expression lines when applied topically. Actual dermal penetration and clinical efficacy from topical use are debated.
Research-reported dosing
Used topically, typically formulated at around 3-10% of the supplied trade solution in leave-on cosmetic products, applied once or twice daily. It is a cosmetic ingredient, not an approved or injectable drug; no systemic dosing applies.
Not reconstituted for injection - SNAP-8 is supplied as a cosmetic-grade solution or powder for topical formulation into leave-on creams and serums. Bacteriostatic-water injection mixing does not apply.
Open this mix in the calculator →Dosing figures describe how this compound appears in the research literature and research-community references. They are not a recommendation for human use.
SNAP-8 FAQ
What is SNAP-8?
SNAP-8 (Acetyl Octapeptide-3) is a topical cosmetic peptide marketed as a neuromodulating anti-wrinkle ingredient. It is an eight-amino-acid fragment modeled on the N-terminus of SNAP-25 and is used in leave-on skincare rather than by injection. Evidence is largely manufacturer- and cosmetic-study based.
What is the half-life of SNAP-8?
Not applicable as a systemic drug; used topically. Skin residence and penetration, rather than plasma half-life, are the relevant parameters.
What is the research-reported dosing for SNAP-8?
Used topically, typically formulated at around 3-10% of the supplied trade solution in leave-on cosmetic products, applied once or twice daily. It is a cosmetic ingredient, not an approved or injectable drug; no systemic dosing applies.
How is SNAP-8 reconstituted?
Not reconstituted for injection - SNAP-8 is supplied as a cosmetic-grade solution or powder for topical formulation into leave-on creams and serums. Bacteriostatic-water injection mixing does not apply.
Is SNAP-8 FDA-approved?
No — SNAP-8 is not FDA-approved and is sold for laboratory research use only.
References
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