Matrixyl (palmitoyl pentapeptide-4, Pal-KTTKS) is a topical cosmetic peptide built from a procollagen-derived KTTKS sequence conjugated to a palmitic-acid chain for skin penetration. It is used in anti-aging skincare to support the appearance of firmness and fine lines, based mainly on cosmetic clinical testing.
Mechanism under study
The KTTKS matrikine is a signal fragment reported to stimulate fibroblast synthesis of collagen and extracellular-matrix components; the palmitoyl chain increases lipophilicity to improve stratum-corneum penetration for topical delivery.
Research-reported dosing
Cosmetic use references the raw material at low concentrations (commonly around 3-8% of a supplied trade solution) in leave-on creams and serums applied daily. Combination products (e.g., Matrixyl 3000) pair different palmitoyl peptides. Cosmetic ingredient, not an approved or injectable drug.
Not reconstituted for injection - supplied as a cosmetic-grade solution or powder for topical leave-on formulation. Bacteriostatic-water injection mixing does not apply.
Open this mix in the calculator →Dosing figures describe how this compound appears in the research literature and research-community references. They are not a recommendation for human use.
Matrixyl FAQ
What is Matrixyl?
Matrixyl (palmitoyl pentapeptide-4, Pal-KTTKS) is a topical cosmetic peptide built from a procollagen-derived KTTKS sequence conjugated to a palmitic-acid chain for skin penetration. It is used in anti-aging skincare to support the appearance of firmness and fine lines, based mainly on cosmetic clinical testing.
What is the half-life of Matrixyl?
Not applicable as a systemic drug; used topically. Formulation stability and skin penetration are the relevant parameters rather than plasma half-life.
What is the research-reported dosing for Matrixyl?
Cosmetic use references the raw material at low concentrations (commonly around 3-8% of a supplied trade solution) in leave-on creams and serums applied daily. Combination products (e.g., Matrixyl 3000) pair different palmitoyl peptides. Cosmetic ingredient, not an approved or injectable drug.
How is Matrixyl reconstituted?
Not reconstituted for injection - supplied as a cosmetic-grade solution or powder for topical leave-on formulation. Bacteriostatic-water injection mixing does not apply.
Is Matrixyl FDA-approved?
No — Matrixyl is not FDA-approved and is sold for laboratory research use only.
References
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