For laboratory research use only — not for human or veterinary consumption.
The Peptide Index
PI-040

Argireline

Topical cosmetic hexapeptide

A topical cosmetic hexapeptide (Acetyl Hexapeptide-8) marketed for the appearance of expression lines. It is a skincare ingredient, not an injectable.

Mechanism under study

Argireline mimics part of the SNAP-25 protein and is proposed to interfere with SNARE-complex formation, modestly reducing the muscle contractions associated with expression wrinkles — a topical 'Botox-like' effect, though far weaker.

Research-reported dosing

Cosmetic topical only — formulated in serums and creams, commonly around 5-10%. It is not an injectable, and no systemic dosing is established.

Reconstitution

Not reconstituted for injection — it is a topical cosmetic, typically supplied as an aqueous solution blended into skincare formulations.

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Dosing figures describe how this compound appears in the research literature and research-community references. They are not a recommendation for human use.

Argireline FAQ

What is Argireline?

A topical cosmetic hexapeptide (Acetyl Hexapeptide-8) marketed for the appearance of expression lines. It is a skincare ingredient, not an injectable.

What is the half-life of Argireline?

Not applicable in the injectable sense — it is formulated for topical use.

What is the research-reported dosing for Argireline?

Cosmetic topical only — formulated in serums and creams, commonly around 5-10%. It is not an injectable, and no systemic dosing is established.

How is Argireline reconstituted?

Not reconstituted for injection — it is a topical cosmetic, typically supplied as an aqueous solution blended into skincare formulations.

Is Argireline FDA-approved?

No — Argireline is not FDA-approved and is sold for laboratory research use only.

References

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