MOTS-c Dosage Chart & Schedule
A mitochondrial-derived peptide studied as a metabolic regulator and exercise-mimetic in preclinical models, and of interest in aging and insulin-sensitivity research.
A mitochondrial-derived peptide with no established human dosing. Research-community references commonly land in a roughly 5-10 mg per week range, often split across one or two subcutaneous injections.
Figures describe how MOTS-c is reported in the research literature and research-community references — not a recommendation for human use. For laboratory research only.
Dosage protocols
Commonly referenced research tiers. Start conservative; every compound and study context differs.
- Frequency
- Once weekly
- Weekly total
- 5 mg
- Cycle
- Cycled (e.g., 4-6 weeks)
Lower end of the commonly referenced weekly range, given as a single injection.
- Frequency
- Twice weekly
- Weekly total
- 10 mg
- Cycle
- Cycled (e.g., 4-6 weeks)
Upper end of the referenced range, split into two injections; human dosing remains unestablished.
Preclinical, not established in humans
- Studied mainly in animal and cell models as a metabolic regulator and exercise-mimetic acting via the AMPK energy-sensing pathway.
- Short systemic presence is why references favor intermittent (a few times weekly) rather than continuous dosing.
- There is no established human clinical dose; figures are research-community references only.
Ready to run this protocol?
Dosing is only as good as the vial. MOTS-c is third-party tested with published COAs from our top-rated source — reconstitute with confidence and skip the guesswork on identity and purity.
Weekly schedule
A typical week on the standard protocol (Twice weekly).
Dosing day Off
MOTS-c reconstitution
Based on a standard 10 mg vial: with 2 mL bacteriostatic water = 5,000 mcg/mL (5 mg/mL); 1 unit ≈ 50 mcg.
From vial to injection in 6 steps
Wipe both vial tops
Swab the peptide vial and the bacteriostatic-water vial with fresh alcohol and let them dry.
Draw the water
Pull the planned amount of bacteriostatic water (2 mL) into the syringe.
Add it slowly
Run the water down the inside wall of the vial — don't blast the powder. Swirl gently; never shake.
Let it dissolve
Wait until the solution is fully clear, then refrigerate the vial.
Draw your dose
Pull the calculated units on a U-100 insulin syringe (~100 units for 5 mg).
Store between uses
Keep the reconstituted vial refrigerated and use within its stable window.
Handling & storage
- A 10 mg vial + 2 mL bacteriostatic water = 5 mg/mL, so a 5 mg dose is 1 mL - a full U-100 syringe.
- Reconstituting the 10 mg vial with 1 mL instead gives 10 mg/mL, halving the injection volume (5 mg = about 50 units).
- Refrigerate after reconstitution and keep the lyophilized powder cool and dark.
MOTS-c dosing FAQ
How often is MOTS-c dosed?
Its short systemic presence leads references to favor intermittent dosing - commonly one to two times weekly rather than daily - with a weekly total often cited around 5-10 mg.
Is there an established human dose?
No. Most evidence is preclinical, so any figure is a research-community reference rather than a validated human protocol.
How do I keep the shot volume reasonable?
At 5 mg/mL a 5 mg dose is a full 1 mL syringe; mixing the 10 mg vial with 1 mL of water (10 mg/mL) cuts that to about 0.5 mL, or the dose can be split across two injections.
Sources
Categories: Longevity & Cellular, GLP-1 & Metabolic · Status: Research use only. This page is educational and for laboratory research use only; it is not medical advice.