Melanotan II Dosage Chart & Schedule
A synthetic melanocortin agonist studied for skin pigmentation (tanning) and, secondarily, arousal. It is not approved, and research notes meaningful safety considerations.
An unapproved melanocortin agonist. Research-community protocols reference a loading phase of roughly 0.25-0.5 mg daily, then a maintenance phase of about 0.5-1 mg two to three times weekly once the desired pigmentation is reached.
Figures describe how Melanotan II is reported in the research literature and research-community references — not a recommendation for human use. For laboratory research only.
Dosage protocols
Commonly referenced research tiers. Start conservative; every compound and study context differs.
- Frequency
- Once daily
- Weekly total
- ~1.75-3.5 mg/week
- Cycle
- Loading phase
Loading phase; low daily amounts are referenced to build pigmentation gradually and limit nausea.
- Frequency
- 2-3x weekly
- Weekly total
- ~1-3 mg/week
- Cycle
- Ongoing after loading
Reduced frequency once the target pigmentation is reached; it is unapproved and carries noted safety considerations.
Unapproved; safety considerations
- Non-selectively activates melanocortin receptors, driving melanogenesis (MC1R) and influencing appetite and arousal (MC4R).
- Not approved; research notes mole and pigmentation changes and nausea as meaningful safety considerations.
Ready to run this protocol?
Dosing is only as good as the vial. Melanotan II is third-party tested with published COAs from our top-rated source — reconstitute with confidence and skip the guesswork on identity and purity.
Weekly schedule
A typical week on the maintenance protocol (2-3x weekly).
Dosing day Off
Melanotan II reconstitution
Based on a standard 10 mg vial: with 2 mL bacteriostatic water = 5,000 mcg/mL (5 mg/mL); 1 unit ≈ 50 mcg.
From vial to injection in 6 steps
Wipe both vial tops
Swab the peptide vial and the bacteriostatic-water vial with fresh alcohol and let them dry.
Draw the water
Pull the planned amount of bacteriostatic water (2 mL) into the syringe.
Add it slowly
Run the water down the inside wall of the vial — don't blast the powder. Swirl gently; never shake.
Let it dissolve
Wait until the solution is fully clear, then refrigerate the vial.
Draw your dose
Pull the calculated units on a U-100 insulin syringe (~10 units for 500 mcg).
Store between uses
Keep the reconstituted vial refrigerated and use within its stable window.
Handling & storage
- A 10 mg vial + 2 mL bacteriostatic water = 5 mg/mL, so 0.5 mg draws to about 10 units on a U-100 syringe.
- Doses are small, so measure carefully; a more dilute mix can improve dosing precision at the low end.
- Refrigerate after reconstitution and keep the lyophilized powder cool and dark.
Melanotan II dosing FAQ
What is the loading phase?
References describe a loading phase of roughly 0.25-0.5 mg daily to build pigmentation, then a switch to a lower-frequency maintenance schedule once the target is reached.
How often during maintenance?
Commonly referenced at about 0.5-1 mg two to three times weekly, rather than daily, once the desired pigmentation is established.
What draws up on a syringe?
From a 10 mg vial in 2 mL (5 mg/mL): 0.25 mg = about 5 units, 0.5 mg = about 10 units, 1 mg = about 20 units on a U-100 insulin syringe.
Sources
Categories: Cosmetic & Skin, Sexual Health · Status: Research use only. This page is educational and for laboratory research use only; it is not medical advice.