Gonadorelin Dosage Chart & Schedule
A synthetic form of gonadotropin-releasing hormone (GnRH). It has established diagnostic and fertility uses and is also used off-label to support endogenous hormone production.
Gonadorelin's dose depends entirely on context: about 100 mcg once as a diagnostic agent, tiny 5-20 mcg pulses every ~90 minutes by pump for fertility, or roughly 100-200 mcg a few times weekly in off-label endocrine-support use. Its half-life is only minutes.
Figures describe how Gonadorelin is reported in the research literature and research-community references — not a recommendation for human use. For laboratory research only.
Dosage protocols
Commonly referenced research tiers. Start conservative; every compound and study context differs.
- Frequency
- 2x/week
- Weekly total
- ~200 mcg/week
- Cycle
- Ongoing alongside TRT in community use
Lower-frequency entry point in endocrine-support protocols.
- Frequency
- 3x/week (approx. EOD)
- Weekly total
- ~300 mcg/week
- Cycle
- Ongoing
A commonly referenced testicular-support frequency.
- Frequency
- 2-3x/week
- Weekly total
- ~400-600 mcg/week
- Cycle
- Ongoing
Top of the referenced 100-200 mcg per-dose range.
Pulsatile vs continuous changes the effect
- Pulsatile delivery stimulates pituitary LH and FSH release.
- Continuous, non-pulsatile exposure instead downregulates the axis.
- This is why GnRH is used both to drive fertility and, as agonists, to suppress hormones.
Context defines the dose
- Diagnostic use is a single dose of about 100 mcg.
- Fertility pumps deliver 5-20 mcg pulses roughly every 90 minutes.
- Community endocrine-support use references ~100-200 mcg a few times weekly.
Ready to run this protocol?
Dosing is only as good as the vial. Research-grade peptides are third-party tested with published COAs from our top-rated source — reconstitute with confidence and skip the guesswork on identity and purity.
Weekly schedule
A typical week on the standard support protocol (3x/week (approx. EOD)).
Dosing day Off
Gonadorelin reconstitution
2 mg vial + 2 mL bacteriostatic water = 1000 mcg/mL.
From vial to injection in 6 steps
Wipe both vial tops
Swab the peptide vial and the bacteriostatic-water vial with fresh alcohol and let them dry.
Draw the water
Pull the planned amount of bacteriostatic water (2 mL) into the syringe.
Add it slowly
Run the water down the inside wall of the vial — don't blast the powder. Swirl gently; never shake.
Let it dissolve
Wait until the solution is fully clear, then refrigerate the vial.
Draw your dose
Pull the calculated units on a U-100 insulin syringe (~10 units for 100 mcg).
Store between uses
Keep the reconstituted vial refrigerated and use within its stable window.
Handling & storage
- A 2 mg vial with 2 mL bacteriostatic water gives 1000 mcg/mL, so 100 mcg is about 0.1 mL (10 units).
- Reconstitute gently and store the solution refrigerated.
- The minutes-long half-life is why clinical fertility use relies on a pulsatile pump.
- Has approved diagnostic/fertility uses; the testicular-support use is off-label.
Gonadorelin dosing FAQ
Why are there so many different gonadorelin doses?
Because the use cases differ: a one-time ~100 mcg diagnostic dose, 5-20 mcg pump pulses for fertility, and ~100-200 mcg a few times weekly for off-label endocrine support are all documented.
How do I measure 100 mcg on a syringe?
From a 2 mg vial in 2 mL water (1000 mcg/mL), 100 mcg is 0.1 mL - about 10 units on a U-100 insulin syringe.
Why does clinical fertility use need a pump instead of a few weekly shots?
Natural GnRH is released in pulses. Reproducing that pattern requires small doses every ~90 minutes, which a pump delivers; continuous exposure would suppress rather than stimulate the axis.
How often is it dosed in the community endocrine-support context?
References commonly cite 100 mcg two to three times weekly (often every other day), sometimes up to 200 mcg per dose. This use is off-label and not an established regimen.
Sources
Categories: Sexual Health · Status: Research use only. This page is educational and for laboratory research use only; it is not medical advice.