Dulaglutide Dosage Chart & Schedule
Dulaglutide (Trulicity) is an FDA-approved once-weekly GLP-1 receptor agonist for type 2 diabetes and cardiovascular risk reduction. It is a fusion protein linking two modified GLP-1 analog peptides to a human IgG4 Fc fragment, which substantially extends its half-life.
Dulaglutide (Trulicity) is a once-weekly subcutaneous GLP-1 receptor agonist supplied in single-dose prefilled pens (not reconstituted). Labeling uses 0.75 mg or 1.5 mg weekly, with titration options up to 3.0 mg and 4.5 mg weekly.
Figures describe how Dulaglutide is reported in the research literature and research-community references — not a recommendation for human use. For laboratory research only.
Dosage protocols
Commonly referenced research tiers. Start conservative; every compound and study context differs.
- Frequency
- Once weekly
- Weekly total
- 0.75 mg/week
- Cycle
- Ongoing
Lowest labeled dose; a common starting point.
- Frequency
- Once weekly
- Weekly total
- 1.5 mg/week
- Cycle
- Ongoing
Common maintenance dose.
- Frequency
- Once weekly
- Weekly total
- 3.0-4.5 mg/week
- Cycle
- Ongoing after titration
Higher labeled titration options.
A fixed-dose pen, not a vial
- Dulaglutide is an IgG4-Fc fusion protein supplied as a single-dose prefilled pen.
- As a large (~60 kDa) fusion protein it is not handled like a lyophilized research peptide.
- There is no bacteriostatic-water mix or unit conversion.
Once-weekly by design
- Half-life is about 5 days, supporting once-weekly dosing.
- The Fc fusion resists DPP-4 cleavage and renal clearance.
Ready to run this protocol?
Dosing is only as good as the vial. Research-grade peptides are third-party tested with published COAs from our top-rated source — reconstitute with confidence and skip the guesswork on identity and purity.
Weekly schedule
A typical week on the standard maintenance protocol (Once weekly).
Dosing day Off
From vial to injection in 6 steps
Wipe both vial tops
Swab the peptide vial and the bacteriostatic-water vial with fresh alcohol and let them dry.
Draw the water
Pull the planned amount of bacteriostatic water (per your mix) into the syringe.
Add it slowly
Run the water down the inside wall of the vial — don't blast the powder. Swirl gently; never shake.
Let it dissolve
Wait until the solution is fully clear, then refrigerate the vial.
Draw your dose
Pull the calculated units on a U-100 insulin syringe.
Store between uses
Keep the reconstituted vial refrigerated and use within its stable window.
Handling & storage
- Supplied as single-dose prefilled pens - nothing to reconstitute or measure.
- Inject subcutaneously once weekly on the same day each week; rotate sites.
- Refrigerate pens; a limited room-temperature window is allowed per labeling.
- FDA-approved (2014) for type 2 diabetes and cardiovascular risk reduction.
Dulaglutide dosing FAQ
How often is dulaglutide dosed?
Once weekly, on the same day each week. Its ~5-day half-life and Fc-fusion design support weekly rather than daily dosing.
What weekly doses are available?
Labeling describes 0.75 mg and 1.5 mg weekly, with titration options to 3.0 mg and 4.5 mg weekly for additional glucose control.
Is dulaglutide reconstituted from powder?
No. It is a ready-to-use single-dose prefilled pen. As a large Fc-fusion protein it is not prepared like a lyophilized research peptide.
Which dose do people usually start on?
0.75 mg once weekly is a common starting dose, often maintained or stepped up to 1.5 mg and beyond based on response.
Sources
Categories: GLP-1 & Metabolic · Status: Approved (see notes). This page is educational and for laboratory research use only; it is not medical advice.