VIP (Vasoactive Intestinal Peptide) Dosage Chart & Schedule
Vasoactive intestinal peptide (VIP) is a 28-amino-acid neuropeptide with broad roles in vasodilation, smooth-muscle relaxation, secretion, and immune regulation. A synthetic form, aviptadil, has been investigated clinically for respiratory and pulmonary conditions. Some research communities use intranasal VIP; the systemic half-life is very short.
Research-community VIP protocols are usually intranasal, citing roughly 50 mcg per spray several times daily because the plasma half-life is only 1-2 minutes. The clinical form, aviptadil, is instead given as a controlled IV infusion and is investigational.
Figures describe how VIP (Vasoactive Intestinal Peptide) is reported in the research literature and research-community references — not a recommendation for human use. For laboratory research only.
Dosage protocols
Commonly referenced research tiers. Start conservative; every compound and study context differs.
- Frequency
- 1-2x daily
- Weekly total
- ~350-700 mcg/week
- Cycle
- Varies
Fewer daily administrations at the same per-spray amount.
- Frequency
- Several times daily (e.g., 3-4x)
- Weekly total
- ~1,000-1,400 mcg/week
- Cycle
- Varies
The commonly cited research-community intranasal pattern.
Very short half-life drives the route
- VIP signals through VPAC1/VPAC2 receptors to raise cyclic AMP, producing vasodilation, bronchodilation, and immunomodulatory effects.
- Its plasma half-life is only about 1-2 minutes, which is why clinical aviptadil is infused IV and why research communities use frequent intranasal microgram dosing instead.
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Weekly schedule
A typical week on the standard intranasal protocol (Several times daily (e.g., 3-4x)).
Dosing day Off
Handling & storage
- Research VIP is commonly prepared as an intranasal solution rather than a subcutaneous injection.
- If a lyophilized vial is reconstituted, 5 mg in 2 mL gives 2.5 mg/mL; intranasal microgram dosing then uses only a small fraction of a mL per spray.
- Keep the reconstituted solution refrigerated; the peptide is delicate, so prepare and use carefully.
- Aviptadil (the clinical IV form) is investigational; VIP is not an approved general-use drug.
VIP (Vasoactive Intestinal Peptide) dosing FAQ
How is VIP dosed in research?
Research-community intranasal protocols cite roughly 50 mcg per spray several times daily. The clinical form, aviptadil, is dosed very differently, as a controlled IV infusion.
Why is VIP given intranasally and so frequently?
Its plasma half-life is only about 1-2 minutes, so systemic injection is impractical outside a controlled infusion; frequent intranasal microgram dosing is the common workaround.
Is intranasal VIP the same as aviptadil?
They are the same peptide, but aviptadil refers to the investigational clinical product studied as an IV infusion at microgram levels, not the intranasal research protocol.
How much solution is one intranasal dose?
At 2.5 mg/mL, a 50 mcg dose is only about 0.02 mL, so a metered nasal spray delivering microgram amounts is used rather than a syringe.
Sources
Categories: Immune & Gut · Status: Investigational. This page is educational and for laboratory research use only; it is not medical advice.