Thymosin Alpha-1 Dosage Chart & Schedule
An immune-modulating 28-amino-acid peptide, marketed as Zadaxin in a number of countries. It is among the more clinically studied immune peptides, though it is not FDA-approved in the United States.
Thymosin Alpha-1 is an immune-modulating peptide marketed as Zadaxin in a number of countries, most often given as 1.6 mg subcutaneously twice weekly. It is not FDA-approved in the United States.
Figures describe how Thymosin Alpha-1 is reported in the research literature and research-community references — not a recommendation for human use. For laboratory research only.
Dosage protocols
Commonly referenced research tiers. Start conservative; every compound and study context differs.
- Frequency
- 2x/week
- Weekly total
- 3.2 mg
- Cycle
- Course of weeks to months
Common regimen for hepatitis and as an immune adjuvant in countries where it is approved.
- Frequency
- 2x/day
- Weekly total
- ~22.4 mg
- Cycle
- Short course (days)
Some critical-illness research used 1.6 mg twice daily short-term rather than twice weekly.
Approved abroad as Zadaxin
- Approved in a number of countries (as Zadaxin/thymalfasin) for hepatitis and as an immune adjuvant.
- Not FDA-approved in the United States.
Ready to run this protocol?
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Weekly schedule
A typical week on the standard (zadaxin regimen) protocol (2x/week).
Dosing day Off
Thymosin Alpha-1 reconstitution
10 mg vial + 2 mL bacteriostatic water = 5000 mcg/mL (5 mg/mL). (The approved Zadaxin presentation is a 1.6 mg single-dose vial.)
From vial to injection in 6 steps
Wipe both vial tops
Swab the peptide vial and the bacteriostatic-water vial with fresh alcohol and let them dry.
Draw the water
Pull the planned amount of bacteriostatic water (2 mL) into the syringe.
Add it slowly
Run the water down the inside wall of the vial — don't blast the powder. Swirl gently; never shake.
Let it dissolve
Wait until the solution is fully clear, then refrigerate the vial.
Draw your dose
Pull the calculated units on a U-100 insulin syringe (~32 units for 1.6 mg).
Store between uses
Keep the reconstituted vial refrigerated and use within its stable window.
Handling & storage
- Reconstitute with bacteriostatic water (a 10 mg vial in about 2 mL gives 5,000 mcg/mL); the approved Zadaxin presentation is a 1.6 mg single-dose vial.
- At 5,000 mcg/mL a 1.6 mg dose is about 0.32 mL (roughly 32 units) on a U-100 syringe.
- Refrigerate the reconstituted solution and rotate subcutaneous injection sites.
Thymosin Alpha-1 dosing FAQ
What is the standard research regimen?
The most-referenced regimen is 1.6 mg subcutaneously twice weekly, matching the approved Zadaxin dosing in countries where it is marketed.
How much is given per injection?
The standard per-injection amount is 1.6 mg, the approved single-dose vial strength.
Does dosing change in acute-illness studies?
Yes. Some critical-illness research used the same 1.6 mg dose but more frequently, such as twice daily over a short course.
Is Thymosin Alpha-1 FDA-approved?
Not in the United States. It is approved as Zadaxin in a number of other countries.
Sources
Categories: Immune & Gut · Status: Approved (see notes). This page is educational and for laboratory research use only; it is not medical advice.