Somatropin (Recombinant HGH) Dosage Chart & Schedule
Somatropin is recombinant human growth hormone, the 191-amino-acid hormone itself rather than a secretagogue. It is FDA-approved across several growth-hormone-deficiency and growth-failure indications and is the hormone that peptides such as sermorelin, CJC-1295, and the GHRPs prompt the pituitary to release. Because it is the native hormone, its effects and risks are comparatively well characterized.
Somatropin is recombinant human growth hormone dosed in both mg and IU, where about 1 mg equals 3 IU. Adult growth-hormone-deficiency regimens reported in the literature run roughly 0.2-0.4 mg/day (about 0.6-1.2 IU/day) subcutaneously, titrated to IGF-1; this is reported context, not a recommendation.
Figures describe how Somatropin (Recombinant HGH) is reported in the research literature and research-community references — not a recommendation for human use. For laboratory research only.
Dosage protocols
Commonly referenced research tiers. Start conservative; every compound and study context differs.
- Frequency
- Once daily, often evening
- Weekly total
- About 7 IU/week (about 2.3 mg)
- Cycle
- Titration start, adjusted to IGF-1 over weeks
Low end of the adult growth-hormone-deficiency reference range.
- Frequency
- Once daily, often evening
- Weekly total
- About 14 IU/week (about 4.7 mg)
- Cycle
- Ongoing under IGF-1 monitoring in approved use
Near the upper end of the adult labeled reference range.
- Frequency
- Once daily
- Weekly total
- About 7-14 IU/week
- Cycle
- Continuous, individualized to blood IGF-1
The settled dose is titrated to keep IGF-1 in range, so it is individual.
IU and mg conversion
- About 1 mg equals 3 IU of somatropin.
- A 5 mg lyophilized vial is about 15 IU.
- At a 2.5 mg/mL mix, one U-100 unit (0.01 mL) is about 25 mcg, or roughly 0.075 IU.
It is the hormone, not a secretagogue
- Somatropin is growth hormone itself, the 191-amino-acid protein.
- Sermorelin, CJC-1295 and the GHRPs instead prompt the pituitary to release it.
- It is FDA-approved for several growth-hormone-deficiency and growth-failure indications.
Ready to run this protocol?
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Weekly schedule
A typical week on the standard protocol (Once daily, often evening).
Dosing day Off
Somatropin (Recombinant HGH) reconstitution
Some presentations are prefilled pens; a lyophilized 5 mg (about 15 IU) vial reconstituted with 2 mL bacteriostatic water yields 2.5 mg/mL (about 7.5 IU/mL). On a U-100 syringe 1 unit (0.01 mL) is about 25 mcg, or roughly 0.075 IU. Note the conversion of about 1 mg to 3 IU.
From vial to injection in 6 steps
Wipe both vial tops
Swab the peptide vial and the bacteriostatic-water vial with fresh alcohol and let them dry.
Draw the water
Pull the planned amount of bacteriostatic water (2 mL) into the syringe.
Add it slowly
Run the water down the inside wall of the vial — don't blast the powder. Swirl gently; never shake.
Let it dissolve
Wait until the solution is fully clear, then refrigerate the vial.
Draw your dose
Pull the calculated units on a U-100 insulin syringe (~12 units for 300 mcg).
Store between uses
Keep the reconstituted vial refrigerated and use within its stable window.
Handling & storage
- Reconstitute gently down the vial wall; do not shake, which can damage the protein.
- A 5 mg (about 15 IU) vial with 2 mL bacteriostatic water gives 2.5 mg/mL (about 7.5 IU/mL).
- Refrigerate reconstituted product at 2-8 C and keep it out of light.
- Rotate subcutaneous injection sites to reduce fat loss at any one spot.
Somatropin (Recombinant HGH) dosing FAQ
How do I convert somatropin mg to IU?
About 1 mg is 3 IU, so a 5 mg vial is roughly 15 IU. At a 2.5 mg/mL mix, one U-100 unit is about 25 mcg or 0.075 IU.
What daily dose do adult studies report?
Adult growth-hormone-deficiency regimens report roughly 0.2-0.4 mg/day (about 0.6-1.2 IU) subcutaneously, titrated to IGF-1 rather than a fixed number. This is reported context, not a recommendation.
When is it usually injected?
It is typically given once daily by subcutaneous injection, often in the evening to loosely mirror natural nighttime growth-hormone release.
How is the dose adjusted over time?
In approved use the dose is titrated to keep blood IGF-1 within an age-appropriate range, so the settled maintenance amount is individualized.
Is somatropin dosed differently in children?
Pediatric growth indications are weight-based and generally higher per kilogram than adult regimens; those are clinical protocols, not self-dosing references.
Sources
- Somatropin and growth hormone deficiency (PubMed search) ↗
- Recombinant human growth hormone and IGF-1 (PubMed search) ↗
Categories: Growth Hormone Secretagogues · Status: Approved (see notes). This page is educational and for laboratory research use only; it is not medical advice.