Sermorelin Dosage Chart & Schedule
A GHRH (1-29) analog — the shortest fully active fragment of GHRH — historically used clinically as a diagnostic agent and studied for supporting endogenous growth-hormone output.
Research references commonly cite ~100-300 mcg once daily, usually pre-sleep to align with the natural nighttime GH pulse. Historically used clinically as a diagnostic agent; general dosing is a research convention.
Figures describe how Sermorelin is reported in the research literature and research-community references — not a recommendation for human use. For laboratory research only.
Dosage protocols
Commonly referenced research tiers. Start conservative; every compound and study context differs.
- Frequency
- Once daily (pre-sleep)
- Weekly total
- 0.7 mg
- Cycle
- 8-12 weeks, then reassess
A conservative nightly starting reference given the very short half-life.
- Frequency
- Once daily (pre-sleep)
- Weekly total
- 1.4-2.1 mg
- Cycle
- 8-12 weeks, then reassess
The most commonly referenced nightly range, timed to the body's largest natural GH pulse.
Formerly an approved drug
- Sermorelin (as Geref) was historically marketed and used clinically, including as a diagnostic test of pituitary GH reserve.
- The branded product was later discontinued; it now appears mainly as a research and compounded compound.
Timed to natural GH pulses
- References commonly cite a pre-sleep dose on an empty stomach to align with the largest natural nighttime GH pulse.
- As a GHRH (1-29) analog it preserves feedback regulation; the very short half-life (~10-20 min) drives once-daily timing.
Ready to run this protocol?
Dosing is only as good as the vial. Research-grade peptides are third-party tested with published COAs from our top-rated source — reconstitute with confidence and skip the guesswork on identity and purity.
Weekly schedule
A typical week on the standard protocol (Once daily (pre-sleep)).
Dosing day Off
Sermorelin reconstitution
5 mg vial + 2 mL bacteriostatic water = 2500 mcg/mL.
From vial to injection in 6 steps
Wipe both vial tops
Swab the peptide vial and the bacteriostatic-water vial with fresh alcohol and let them dry.
Draw the water
Pull the planned amount of bacteriostatic water (2 mL) into the syringe.
Add it slowly
Run the water down the inside wall of the vial — don't blast the powder. Swirl gently; never shake.
Let it dissolve
Wait until the solution is fully clear, then refrigerate the vial.
Draw your dose
Pull the calculated units on a U-100 insulin syringe (~12 units for 300 mcg).
Store between uses
Keep the reconstituted vial refrigerated and use within its stable window.
Handling & storage
- Reconstitute with bacteriostatic water (2 mL into a 5 mg vial = 2500 mcg/mL)
- Refrigerate reconstituted; sermorelin is relatively unstable in solution, so use within a few weeks
- A 300 mcg dose draws to ~12 units on a U-100 insulin syringe
Sermorelin dosing FAQ
How much sermorelin per night?
Research references commonly cite ~100-300 mcg once daily, usually pre-sleep, or roughly 0.7-2.1 mg/week.
How is sermorelin reconstituted?
With bacteriostatic water. For example, 2 mL into a 5 mg vial = 2500 mcg/mL, so a 300 mcg dose is about 12 units on a U-100 syringe.
When should sermorelin be taken?
Research protocols reference a pre-sleep dose on an empty stomach to align with the natural nighttime GH pulse.
Is sermorelin the same as CJC-1295?
Both are GHRH (1-29) analogs, but CJC-1295 adds modifications that make it longer-acting, whereas sermorelin is very short-acting (~10-20 min).
Sources
Categories: Growth Hormone Secretagogues · Status: Research use only. This page is educational and for laboratory research use only; it is not medical advice.