For laboratory research use only — not for human or veterinary consumption.
The Peptide Index
Dosing guide

Semax Dosage Chart & Schedule

A synthetic peptide derived from a fragment of ACTH, developed in Russia and studied for nootropic and neuroprotective effects, typically administered intranasally in research.

Route
Intranasal
Frequency
Daily (nasal)
Half-life
Short in plasma
Storage
Refrigerate reconstituted; keep lyophilized cool + dark
The short answer

Typically administered intranasally in research. References commonly cite about 200-600 mcg per dose, given one to three times daily; most human evidence is from Russian clinical research and it is not FDA-approved.

Figures describe how Semax is reported in the research literature and research-community references — not a recommendation for human use. For laboratory research only.

Dosage protocols

Commonly referenced research tiers. Start conservative; every compound and study context differs.

Starter
200-300 mcg
per intranasal dose
Frequency
1-2x daily
Weekly total
~1.4-4.2 mg/week
Cycle
2-4 week courses

Lower end of the referenced intranasal range, split across the day.

Most commonStandard
300-600 mcg
per intranasal dose
Frequency
2-3x daily
Weekly total
~4-12 mg/week
Cycle
2-4 week courses

Upper end of the referenced range, divided into daily intranasal doses.

Intranasal, Russian clinical origin

  • Derived from an ACTH fragment and developed in Russia; studied for nootropic and neuroprotective effects and not FDA-approved.
  • Sold in different labeled concentrations (e.g., 0.1% versus 1% nasal solutions), so per-drop content varies with the formulation.

Ready to run this protocol?

Dosing is only as good as the vial. Semax is third-party tested with published COAs from our top-rated source — reconstitute with confidence and skip the guesswork on identity and purity.

Weekly schedule

A typical week on the standard protocol (2-3x daily).

Mon
Tue
Wed
Thu
Fri
Sat
Sun

Dosing day Off

Handling & storage

  • Often supplied or prepared as a nasal solution; from a 10 mg vial + 2 mL diluent = 5 mg/mL, a 300 mcg dose is about 0.06 mL.
  • Check the labeled concentration (0.1% vs 1%) before dosing, since per-drop content differs substantially.
  • Refrigerate the reconstituted solution and keep any lyophilized powder cool and dark.

Semax dosing FAQ

How is Semax dosed?

Most research uses intranasal administration of about 200-600 mcg per dose, split one to three times daily.

Why do product strengths differ?

Semax nasal solutions are sold in different concentrations (commonly 0.1% and 1%), so the same number of drops delivers very different amounts; always check the label.

Is it approved?

No. Most human evidence comes from Russian clinical research, and it is not FDA-approved.

Sources

Categories: Nootropic & Cognitive · Status: Approved (see notes). This page is educational and for laboratory research use only; it is not medical advice.