PT-141 Dosage Chart & Schedule
A melanocortin-receptor agonist, FDA-approved as Vyleesi for hypoactive sexual desire disorder in premenopausal women. Studied for arousal via central nervous-system pathways rather than the vascular route.
Used as needed before anticipated activity rather than on a daily schedule. The approved Vyleesi dose is 1.75 mg subcutaneously, with limits of no more than one dose per 24 hours and a monthly cap.
Figures describe how PT-141 is reported in the research literature and research-community references — not a recommendation for human use. For laboratory research only.
Dosage protocols
Commonly referenced research tiers. Start conservative; every compound and study context differs.
- Frequency
- As needed
- Weekly total
- As needed (not daily)
- Cycle
- Not daily; assess nausea
Lower amount sometimes referenced first to gauge nausea, which is a common labeled effect.
- Frequency
- As needed
- Weekly total
- As needed (not daily)
- Cycle
- Max 1 dose/24h; monthly cap
Matches the approved Vyleesi single-use dose taken before anticipated activity.
As-needed, with caps
- Approved as Vyleesi for hypoactive sexual desire disorder in premenopausal women; the labeled dose is 1.75 mg subcutaneously before anticipated activity.
- Labeling limits use to no more than one dose in 24 hours and no more than eight doses per month.
- Nausea is a common labeled effect, which is why a lower first dose is sometimes referenced.
Ready to run this protocol?
Dosing is only as good as the vial. PT-141 is third-party tested with published COAs from our top-rated source — reconstitute with confidence and skip the guesswork on identity and purity.
PT-141 reconstitution
Based on a standard 10 mg vial: with 2 mL bacteriostatic water = 5,000 mcg/mL (5 mg/mL); 1 unit ≈ 50 mcg.
From vial to injection in 6 steps
Wipe both vial tops
Swab the peptide vial and the bacteriostatic-water vial with fresh alcohol and let them dry.
Draw the water
Pull the planned amount of bacteriostatic water (2 mL) into the syringe.
Add it slowly
Run the water down the inside wall of the vial — don't blast the powder. Swirl gently; never shake.
Let it dissolve
Wait until the solution is fully clear, then refrigerate the vial.
Draw your dose
Pull the calculated units on a U-100 insulin syringe (~35 units for 1.75 mg).
Store between uses
Keep the reconstituted vial refrigerated and use within its stable window.
Handling & storage
- A 10 mg vial + 2 mL bacteriostatic water = 5 mg/mL, so 1.75 mg draws to about 35 units on a U-100 syringe.
- It is dosed occasionally, so one reconstituted vial lasts many doses; refrigerate between uses.
- Keep the lyophilized powder cool and dark before mixing.
PT-141 dosing FAQ
Is PT-141 taken daily?
No. It is used as needed before anticipated activity, and labeling caps it at one dose per 24 hours and eight doses per month.
What is the reference dose?
The approved Vyleesi dose is 1.75 mg subcutaneously; some references start at about 1 mg to gauge nausea, a common labeled effect.
What draws up on a syringe?
From a 10 mg vial in 2 mL (5 mg/mL): 1 mg = about 20 units and 1.75 mg = about 35 units on a U-100 insulin syringe.
Sources
Categories: Sexual Health · Status: Approved (see notes). This page is educational and for laboratory research use only; it is not medical advice.