MK-677 Dosage Chart & Schedule
MK-677 (Ibutamoren) is an orally active growth hormone secretagogue that mimics ghrelin at the GHS-R1a receptor. Despite being grouped with research peptides, it is a small non-peptide molecule taken by mouth rather than injected. It remains investigational and is not an approved drug in the United States.
MK-677 (Ibutamoren) is an orally dosed small molecule, not an injectable peptide, so it is not reconstituted. Clinical research has examined roughly 10-25 mg by mouth once daily; it remains investigational and is not FDA-approved.
Figures describe how MK-677 is reported in the research literature and research-community references — not a recommendation for human use. For laboratory research only.
Dosage protocols
Commonly referenced research tiers. Start conservative; every compound and study context differs.
- Frequency
- Once daily
- Weekly total
- ~70 mg/week
- Cycle
- Studied over weeks to months
Lower end of the researched oral range.
- Frequency
- Once daily
- Weekly total
- ~140 mg/week
- Cycle
- Studied over weeks to 1-2 years
Mid-to-upper commonly referenced oral dose.
- Frequency
- Once daily
- Weekly total
- ~175 mg/week
- Cycle
- Studied over weeks to months
Upper end referenced in clinical research.
Oral, not injected
- MK-677 is a non-peptide small molecule taken by mouth.
- It is not reconstituted with bacteriostatic water and has no per-injection unit math.
- Research material is supplied as capsules or an oral liquid.
Long-lived effect
- Plasma half-life is about 4-6 hours, consistent with once-daily dosing.
- GH and IGF-1 elevations persist longer than the plasma level alone would suggest.
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Weekly schedule
A typical week on the standard protocol (Once daily).
Dosing day Off
Handling & storage
- Dosed orally once daily; there is nothing to reconstitute or draw into a syringe.
- Studies commonly give it before bed to align with natural GH pulses.
- Store capsules or oral liquid cool, dry, and sealed away from light.
- Investigational - not FDA-approved for any indication.
MK-677 dosing FAQ
Do I reconstitute MK-677 like an injectable peptide?
No. MK-677 is an oral small molecule taken as a capsule or liquid, so bacteriostatic water and unit conversions do not apply.
What oral dose is used in research?
Clinical research has examined roughly 10-25 mg once daily, studied over periods ranging from weeks to as long as 1-2 years.
Why once daily if the half-life is only 4-6 hours?
A single daily dose produces sustained elevations in GH and IGF-1 that outlast the plasma level, so studies generally use once-daily dosing, often at night.
Is MK-677 a steroid or an injectable?
Neither. It is an oral ghrelin-receptor agonist (a growth-hormone secretagogue), not a steroid and not injected.
Sources
Categories: Growth Hormone Secretagogues · Status: Approved (see notes). This page is educational and for laboratory research use only; it is not medical advice.