Mazdutide Dosage Chart & Schedule
A once-weekly GLP-1/glucagon dual receptor agonist based on the gut hormone oxyntomodulin. It has been approved in China for weight management and remains investigational in other regions.
Mazdutide is a once-weekly GLP-1/glucagon dual receptor agonist based on the gut hormone oxyntomodulin, given subcutaneously and titrated upward. Phase 3 programs studied roughly the 4-6 mg weekly range; it is approved in China for weight management and remains investigational elsewhere.
Figures describe how Mazdutide is reported in the research literature and research-community references — not a recommendation for human use. For laboratory research only.
Dosage protocols
Commonly referenced research tiers. Start conservative; every compound and study context differs.
- Frequency
- Once weekly
- Weekly total
- ~1-3 mg
- Cycle
- Titrate up over weeks
Trials began below the target dose and escalated.
- Frequency
- Once weekly
- Weekly total
- 4 mg
- Cycle
- Ongoing
One of the doses approved in China (2025) for chronic weight management.
- Frequency
- Once weekly
- Weekly total
- 6 mg
- Cycle
- Ongoing
Upper end of the roughly 4-6 mg weekly range.
Approved in China, investigational elsewhere
- Approved in China (2025) for chronic weight management.
- Remains investigational in other regions; figures here are research references.
Oxyntomodulin-based
- Derived from the gut hormone oxyntomodulin, activating both GLP-1 and glucagon receptors to reduce appetite while raising energy expenditure.
Ready to run this protocol?
Dosing is only as good as the vial. Research-grade peptides are third-party tested with published COAs from our top-rated source — reconstitute with confidence and skip the guesswork on identity and purity.
Weekly schedule
A typical week on the standard protocol (Once weekly).
Dosing day Off
Mazdutide reconstitution
5 mg vial + 1 mL bacteriostatic water = 5000 mcg/mL.
From vial to injection in 6 steps
Wipe both vial tops
Swab the peptide vial and the bacteriostatic-water vial with fresh alcohol and let them dry.
Draw the water
Pull the planned amount of bacteriostatic water (1 mL) into the syringe.
Add it slowly
Run the water down the inside wall of the vial — don't blast the powder. Swirl gently; never shake.
Let it dissolve
Wait until the solution is fully clear, then refrigerate the vial.
Draw your dose
Pull the calculated units on a U-100 insulin syringe (~80 units for 4 mg).
Store between uses
Keep the reconstituted vial refrigerated and use within its stable window.
Handling & storage
- Reconstitute the lyophilized powder with bacteriostatic water (a 5 mg vial in 1 mL gives 5,000 mcg/mL); larger weekly totals may require more than one vial.
- Give once weekly by subcutaneous injection on a U-100 syringe, rotating sites.
- Refrigerate the reconstituted vial and protect it from light.
Mazdutide dosing FAQ
How often is mazdutide dosed?
It is long-acting and dosed once weekly by subcutaneous injection.
What dose range was studied?
Phase 3 programs examined roughly the 4-6 mg weekly range, reached by gradual titration.
Is mazdutide approved anywhere?
It was approved in China in 2025 for chronic weight management; it remains investigational in other regions.
Why titrate the dose up?
Gradual escalation across the GLP-1 class helps limit gastrointestinal effects such as nausea.
Sources
Categories: GLP-1 & Metabolic · Status: Approved (see notes). This page is educational and for laboratory research use only; it is not medical advice.